TRIUMF

Exp. No.

M1628 — Approved

Title of Experiment

Muon Spin Spectroscopy of Model Biological Systems: Characterization of the Mu Adduct of Cholesterol

Spokesperson(s) for Group

Safety Coordinator(s) for Group

Current Members of Group

Name Institution Status % of research time devoted to experiment
I. McKenzie TRIUMF, CMMS Research Scientist
M.D. Bridges UC Fullerton, Chemistry Assistant Professor
Thomas Gutberlet FZ Jülich Research Scientist
Robert Scheuermann PSI Research Scientist

Abstract

Cholesterol is an important and ubiquitous molecule in biological systems. This proposal is the first step in what is envisioned as a long-term project that will culminate in studying biologically relevant materials using avoided level crossing muon spin resonance (ALC-muSR) and the muoniated adducts of cholesterol as spin probes. We will quantify for the first time the sensitivity of the Mu adduct of cholesterol to the local polarity. We wish to measure the ALC-muSR spectra of cholesterol in a series of alcohols as a function of increasing alkyl chain length and temperature.